Our Lab engages in studies linking the bench with the bedside that investigate the molecular pathogenesis of human cancers, with a primary focus on pancreatic cancer. Our objective is to enhance responses in patients to treatments that target aberrant signal transduction pathways that drive tumor growth.
Towards this goal we are TAKING AIM at the genetic causes of human pancreatic cancers using next generation experimental methods and models. These tools transform our ability to develop more effective cocktail therapies that destroy tumors. We hope that our work will lead to effective rational combination therapies for cancer patients that will improve their survival.

Yes, we would be most pleased: you can contact us at the mail in the CONTACTS.

Yes, collaborations are essential for our work and for moving the field of cancer therapeutics forward. These collaborations are crucial to use emerging, multidisciplinary, and integrative functional genomics methodologies, highly relevant cell cultures and tumor model systems, and appropriate human tumor specimens to design novel, rational therapeutic strategies and to translate our findings into clinical applications.

Our Lab is grateful for the support of the following foundations and institutions for funding our cancer research (…in the present, past, …and, hopefully, future):

• AIRC (Start-up grant): this is the main funding source for our studies. See the Home page for more details on this grant.
• Bennink Foundation (in collaboration with Prof. Kazemier)
• Cancer Center Amsterdam Foundation (with Dr. Cloos, Dr. Schuurhuis and Dr. Wurdinger)
• EORTC-PAMM (with Prof. Peters, Prof. Minutolo)
• European Union FP7 (with Prof. Peters, Dr. Leon)
• Fondazione Humanitas (with Dr. Zucali)
• Fondazione Veronesi
• ITT – Istituto Toscano Tumori (with Prof. Boggi and Prof. Campani)
• Mesothelioma Applied Research Foundation: “The Law Offices of Peter G. Angelos Grant”
• Netherlands Organization for Scientific Research (NWO)
• Regione Toscana – Bando FAS – Salute (with Prof. Boggi and Dr. Bizzarri)
• University of Pisa – DIPINT (with Prof. Boggi and Prof. Minutolo)
• VUmc-AMC AIO Alliantie (with Dr. Jimenez and Dr. Bijlsma)

Un ringraziamento particolare alla famiglia e tutti quanti hanno voluto mantenere vivo il ricordo di Paolo Zadra sostenendo con la loro generosità la nostra ricerca. Questo rappresenta per noi un ulteriore stimolo ad impegnarci sempre più per fare in modo che i nostri studi possano in future migliorare le terapie per combattere i tumori del pancreas.

It is a pleasant, peaceful city, not too big, not too small, just right. I adapted to the weather–dull gray and drizzly most of the year… Great weather for being indoors with a warm computer.

It is a pleasant, peaceful city, not too big, not too small, just right. I adapted to the weather–warm and quite dry most of the year… Great weather for being outdoors “running” with samples and chemical reagents among different labs.