Resistance mechanisms in new drugs and how to overcome it: the point of view of the pharmacologist

Resistance mechanisms in new drugs and how to overcome it: the point of view of the pharmacologist

Elisa Giovannetti
Cancer Pharmacology Lab, Pisa University, Italy
Lab Medical Oncology, Vumc, Amsterdam, The Netherlands

37th EORTC-PAMM Winter Meeting
Antwerp, Belgium
11 February 2016

Pdf: Resistance mechanisms in new drugs and how to overcome it

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Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells

Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells

Leticia G. Leon
PhD, PharmD

37th EORTC-PAMM Winter Meeting
Antwerp, Belgium
10 February 2016

Pdf: Synergistic activity of the c-Met and tubulin inhibitor tivantinib

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Il mestiere del ricercatore

Il mestiere del ricercatore

Elisa Giovannetti
Azienda Ospedaliera Universitaria di Pisa

Coloro che ritengono di essere “perfetti” non potranno mai progredire, mentre chi ha la coscienza della propria “imperfezione” è costantemente affetto da curiosità e tensione verso il miglioramento, fondamentali per fare nuove scoperte
Rita Levi Montalcini

Incontri con la Ricerca
Aula Magna – Centro Congressi Polo Fibonacci
4 Novembre 2015

Pdf: Il mestire del ricercatore

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Association of AKT1 and SELP Polymorphisms with Cachexia and Survival of Patients with Pancreatic Cancer

Association of AKT1 and SELP Polymorphisms with Cachexia and Survival of Patients with Pancreatic Cancer

Paola Pace, Abolfazl Avan, Andrea Mambrini, Niccola Funel, Tessa Y. Le Large, Maurizio Cantore, Ugo Boggi, Elisa Giovannetti

Carrara Civic Hospital; VU University Medical Center, Amsterdam, The Netherlands; Cancer Pharmacology Lab, AIRC/Start Up Unit, Pisa; Mantova Civic Hospital; University of Pisa and Istituto Toscano Tumori

Congresso Nazionale AISP 2015
October 22, 2015 – Milano (Italy)

Pdf: AISP 2015 – Cachexia

Foto:

IMG_2300

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16th World Conference on Lung Cancer

16th World Conference on Lung Cancer

September 6-9, 2015 – Denver, Colorado, USA

MicroRNA Profiling of a Familial Primary Pulmonary Enteric Adenocarcinoma

Ingrid Garajová, Niccola Funel, Michelangelo Fiorentino, Valentina Agostini, Manuela Ferracin, Massimo Negrini, Giovanni Luca Frassineti, Christian Rolf, Guido Biasco, Elisa Giovannetti

Website: www.iaslc.org

Pdf: Garajová at 16th World Conference on Lung Cancer

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10th Annual Scientific conference of Istituto Toscano Tumori (ITT)

10th Annual Scientific conference of Istituto Toscano Tumori (ITT)

July 1-3, 2015 – Pisa (Italy)

Molecular basis of progression in pancreatic cancer

Niccola Funel

Website: www.ittumori.it

Pdf: Funel at 10th Annual Scientific conference of ITT

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47th Meeting of European Pancreatic Club

47th Meeting of European Pancreatic Club

The Cancer Pharmacology Lab was under the spotlight at the Annual Meeting of the European Pancreatic Club, in Toledo, Spain, 24-26 June 2015

The abstract “Galectin-4 (Gal-4) expression is associated with reduced lymph node metastasis, and the modulation of its downstream pathway Wnt/beta-catenin inhibits invasive behavior of pancreatic cancer (PDAC) cells” was selected as an oral presentation, and presented by Dr. Niccola Funel in the session “Pancreatic Ductal Adenocarcinoma”
During the Gala Dinner, the EPC acknowledged the work of Dr. Giovannetti as an elected Abstract Selection Committee member in the period 2012-2015, giving her the EPC medallion.

Hypoexpression of Galectin-4 inhibits invasive behavior of Primary Pancreatic Adenocarcinoma Cells and is associated with modulation of Wnt/β-catenin Signalling and reduced Lymph Node Metastasis

Niccola Funel
Maftouh M, Belo AI, Avan A, Funel N, Peters GJ, van Die I, Giovannetti E.

Department of Translational Research and The New Technologies in Medicine and Surgery
AIRC-Start-Up, Pisa, Italy

Website: www.epc2015.net

Pdf: Funel at 47th Meeting of European Pancreatic Club

Photos:

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16th International Symposium on Purine and Pyrimidine Metabolism in Man

16th International Symposium on Purine and Pyrimidine Metabolism in Man

June 6-9, 2015 – Columbia University, New York City

Inhibitors of lactate dehydrogenase overcome the resistance towards gemcitabine in hypoxic mesothelioma cells, and modulate the expression of the human equilibrative transporter-1 (hENT1)

Elisa Giovannetti, Leticia G. Leon, Paolo A. Zucali, Filippo Minutolo, Godefridus J Peters

This work was partially supported by grants from “The Law Offices of Peter G. Angelos Grant” from the Mesothelioma Applied Research Foundation (E.G, L.G.L, F.M., G.J.P), EORTC-PAMM (G.J.P, E.G., F.M.), Clinical Research and Innovationscouting” from the University of Pisa (E.G., F.M.), Fondazione Humanitas (E.G, P.A.Z), AIRC/Start-Up (E.G.), European Union Seventh Framework Program [FP7/2007-2013] under grant agreement n° PIIF-GA-2011-299026 (F.M.), and FP7-REGPOT-2012-CT2012-31637-IMBRAIN (L.G.L., E.G., G.J.P.)

Website: www.pps2015.org

Pdf: Inhibitors at 16th International Symposium PPS

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AIRC Start-Up Meeting 2015

AIRC Start-Up Meeting 2015

June 5, 2015 – Verona (Italy)

Bioluminescent pancreatic cancer mouse models from genetically characterized primary cells: a platform for drug discovery

Elisa Giovannetti, MD, PhD
Azienda Ospedaliera Universitaria Pisana

Pdf: Giovannetti at AIRC Start-Up Meeting 2015

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Bioluminescent pancreatic cancer mouse models from genetically characterized primary cells

Bioluminescent pancreatic cancer mouse models from genetically characterized primary cells

A platform for drug discovery and toward personalized treatment in pancreatic cancer

AIRC Start-Up Unit Pisa: Dr. Niccola Funel, Dr. Elisa Giovannetti
Surgery-unit: Dr. N De Lio, Dr. V Perrone, Prof. U Boggi
Oncology-unit: Dr. S Caponi, Dr. E Vasile
Pathology-Unit: Dr. LE Pollina, Prof. D Campani
VUmc Amsterdam collaborators: Dr. T Würdinger, Prof. GJ Peters

Our AIRC-Start-Up research project (poster)

Pdf: Research project poster

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